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- Research Specialist C - Cremins Lab - Penn Engineering and Perleman School of Medicine
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Research Specialist C - Cremins Lab - Penn Engineering and Perleman School of Medicine
University Overview
The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America's Best Large Employers in 2023.
Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.
The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.
Posted Job Title
Research Specialist C - Cremins Lab - Penn Engineering and Perleman School of Medicine
Job Profile Title
Research Specialist C
Job Description Summary
The Cremins lab works at the spatial biology-technology interface to understand chromatin-to-synapse communication during neural circuit activation in the mammalian brain. We aim to understand how chromatin works through long-range physical folding mechanisms to encode neuronal specification and long-term synaptic plasticity in healthy and diseased neural circuits. We pursue a multi-disciplinary approach integrating data across biological scales in the brain, including molecular Chromosome-Conformation-Capture sequencing technologies, single-cell imaging, optogenetics, genome engineering, induced pluripotent stem cell differentiation to neurons/organoids, and in vitro and in vivo electrophysiological measurements.
Our long-term scientific goal is to dissect the fundamental mechanisms by which chromatin architecture causally governs genome function and, ultimately, long-term synaptic plasticity and neural circuit features in healthy mammalian brains as well as during the onset and progression of neurodegenerative and neurodevelopmental disease states.
Our long-term mentorship goal is to develop a diverse cohort of next-generation scientific thinkers and leaders cross-trained in molecular and computational approaches. We seek to create a positive, high-energy environment with open and honest communication to empower individuals to discover and refine their purpose and grow into the best versions of themselves.
Working at Penn Genetics in the Cremins Lab, the researcher will independently design and conduct moderately complex research in the area of genomics sequencing library preparation, molecular cloning, and maxi/mini preps. Maintain and organize lab records. Spearhead the lab's daily operations for: ordering reagents; receiving orders and keeping an orderly lab by ordering reagents in proper locations; leading the fixing of equipment; serving as the first call line for liquid Nitrogen or freezer alarms; handling POs for core facilities at UPenn; organizing and maintaining the lab's -80C, -20C, 4C, and liquid N2 LIMs and ensuring all in the lab maintain their registries; scheduling and coordinating the lab's weekly all hands-on deck activities; serving as the laboratory safety officer.
This role is ideal for you if you enjoy the excitement of a bleeding-edge scientific laboratory and welcome the challenge of serving as a steady consistent organizational and genomics technician role in a fast-paced environment. Those who will thrive in the role are dedicated to collaborative and keen on playing an active role in maintaining excellent protocols, a clean, organized, and safe laboratory, and eager to lead themselves and others toward maintaining a warm, positive, and inclusive lab climate. Organized individuals with a can-do attitude, a passion for building unity and community within a larger laboratory, a knack for independent problem-solving and getting things done, the ability to independently and positively create molecular and cellular data with attention to detail would excel in this role.
Job Description
Job Responsibilities
Scientific
- Independently design and conduct moderately complex research in the area of molecular cloning
- Routinely conduct and lead all Illumina linkering and library preparation for all genomics samples in the Cremins laboratory
- Routinely conduct and lead the kappa quantification, pooling, and placing sequencing runs for the lab
- Serve as the laboratories safety officer
- Lead the assessment and assembly of quotes for fixing and maintenance of technical equipment
- Maintain an orderly lab notebook,; record, interpret, and analyze data within prescribed methods
Administrative
- Carefully curate lab notebooks with detailed record-keeping
- Leadership role in keeping liquid N2 cleaned out, the cell, plasmid, and glycerol stock repositories updated and current, and leading through example to ensure compliance across the lab in tissue culture and cloning standards
- Leadership role in maintaining and organizing laboratory LIMS for -20C, -80C, liquid N2, plasmids, and cold room records
- Laboratory Safety Officer
- Lead the placing of orders
- Lead the receiving of orders and maintaining a clean laboratory with all items placed in their proper place
- Schedule weekly All Hands on Deck lab cleaning endeavors
- Serves as the first or second point of contact for all freezer alarms
Scientific Writing
- Organize, edit, and catalyze the writeup and creation of lab protocols
- Teach and train the laboratory on the lab notebook style and maintain outstanding spreadsheets and records
Operational
- Become an expert in running each piece of equipment in the lab
- Train new lab members on cloning and sequencing protocols
- Write SOPs and protocols for areas under expertise
- Actively involved in establishing and maintaining an orderly, annotated, clean, and organized laboratory with all reagents and boxes in defined location
Qualifications
Master's degree in molecular and cell biology or related field with 3-5 years of related experience or equivalent combination of education and experience. Ability to troubleshoot and solve cellular and genome engineering challenges independently and flexibility and independence to take on new/additional technical tasks that may arise during the discovery process will be important. PhD applicants will be given preference.
Exceptional commitment to building community, belonging, and a collaborative ethos within the laboratory and with the members of other laboratories in Penn Genetics, Epigenetics, and Neuroscience communities
Established track record of working with a dedication to open transparent communication
Demonstrated ability to handle daily laboratory challenges with a dedication to the values of reconciliation, unity, mutual honor, and respect
Must be able to develop excellent wet lab protocols and train/onboard new students and postdocs to educate others in standard lab operating procedures
Job Location - City, State
Philadelphia, Pennsylvania
Department / School
School of Engineering and Applied Science
Pay Range
$43,919.00 - $65,000.00 Annual Rate
Salary offers are made based on the candidate's qualifications, experience, skills, and education as they directly relate to the requirements of the position, as well as internal and market factors and grade profile.
Affirmative Action Statement
Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.
Special Requirements
Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.
University Benefits
- Health, Life, and Flexible Spending Accounts: Penn offers comprehensive medical, prescription, behavioral health, dental, vision, and life insurance benefits to protect you and your family's health and welfare. You can also use flexible spending accounts to pay for eligible health care and dependent care expenses with pre-tax dollars.
- Tuition: Take advantage of Penn's exceptional tuition benefits. You, your spouse, and your dependent children can get tuition assistance here at Penn. Your dependent children are also eligible for tuition assistance at other institutions.
- Retirement: Penn offers generous retirement plans to help you save for your future. Penn's Basic, Matching, and Supplemental retirement plans allow you to save for retirement on a pre-tax or Roth basis. Choose from a wide variety of investment options through TIAA and Vanguard.
- Time Away from Work: Penn provides you with a substantial amount of time away from work during the course of the year. This allows you to relax, take vacations, attend to personal affairs, recover from illness or injury, spend time with family-whatever your personal needs may be.
- Long-Term Care Insurance: In partnership with Genworth Financial, Penn offers faculty and staff (and your eligible family members) long-term care insurance to help you cover some of the costs of long-term care services received at home, in the community or in a nursing facility. If you apply when you're newly hired, you won't have to provide proof of good health or be subject to underwriting requirements. Eligible family members must always provide proof of good health and are subject to underwriting.
- Wellness and Work-life Resources: Penn is committed to supporting our faculty and staff as they balance the competing demands of work and personal life. That's why we offer a wide variety of programs and resources to help you care for your health, your family, and your work-life balance.
- Professional and Personal Development: Penn provides an array of resources to help you advance yourself personally and professionally.
- University Resources: As a member of the Penn community, you have access to a wide range of University resources as well as cultural and recreational activities. Take advantage of the University's libraries and athletic facilities, or visit our arboretum and art galleries. There's always something going on at Penn, whether it's a new exhibit at the Penn Museum, the latest music or theater presentation at the Annenberg Center, or the Penn Relays at Franklin Field to name just a few examples. As a member of the Penn community, you're right in the middle of the excitement-and you and your family can enjoy many of these activities for free.
- Discounts and Special Services: From arts and entertainment to transportation and mortgages, you'll find great deals for University faculty and staff. Not only do Penn arts and cultural centers and museums offer free and discounted admission and memberships to faculty and staff. You can also enjoy substantial savings on other goods and services such as new cars from Ford and General Motors, cellular phone service plans, movie tickets, and admission to theme parks.
- Flexible Work Hours: Flexible work options offer creative approaches for completing work while promoting balance between work and personal commitments. These approaches involve use of non-traditional work hours, locations, and/or job structures.
- Penn Home Ownership Services: Penn offers a forgivable loan for eligible employees interested in buying a home or currently residing in West Philadelphia, which can be used for closing costs or home improvements.
- Adoption Assistance: Penn will reimburse eligible employees on qualified expenses in connection with the legal adoption of an eligible child, such as travel or court fees, for up to two adoptions in your household.
To learn more, please visit: https://www.hr.upenn.edu/PennHR/benefits-pay
To apply, visit https://wd1.myworkdaysite.com/en-US/recruiting/upenn/careers-at-penn/job/SEAS-Bioengineering/Research-Specialist-C---Cremins-Lab---Penn-Engineering-and-Perleman-School-of-Medicine_JR00089844
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